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An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation

Avellino, Roberto ; Havermans, Marije ; Erpelinck, Claudia ; Sanders, Mathijs A. ; Hoogenboezem, Remco ; van de Werken, Harmen J. G. ; Rombouts, Elwin ; van Lom, Kirsten ; van Strien, Paulina M. H. ; Gebhard, Claudia ; Rehli, Michael ; Pimanda, John ; Beck, Dominik ; Erkeland, Stefan ; Kuiken, Thijs ; de Looper, Hans ; Gröschel, Stefan ; Touw, Ivo ; Bindels, Eric ; Delwel, Ruud



Abstract

Neutrophilic differentiation is dependent on CCAAT enhancer-binding protein a (C/EBP alpha), a transcription factor expressed in multiple organs including the bone marrow. Using functional genomic technologies in combination with clustered regularly-interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 genome editing and in vivo mouse modeling, we show that CEBPA is located in ...

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