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Mechanism of early dissemination and metastasis in Her2+ mammary cancer

Harper, Kathryn L. ; Sosa, Maria Soledad ; Entenberg, David ; Hosseini, Hedayatollah ; Cheung, Julie F. ; Nobre, Rita ; Avivar-Valderas, Alvaro ; Nagi, Chandandaneep ; Girnius, Nomeda ; Davis, Roger J. ; Farias, Eduardo F. ; Condeelis, John ; Klein, Christoph A. ; Aguirre-Ghiso, Julio A.



Abstract

Metastasis is the leading cause of cancer-related deaths; metastatic lesions develop from disseminated cancer cells (DCCs) that can remain dormant(1). Metastasis-initiating cells are thought to originate from a subpopulation present in progressed, invasive tumours(2). However, DCCs detected in patients before the manifestation of breast-cancer metastasis contain fewer genetic abnormalities than ...

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