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Prognostic relevance of miRNA-155 methylation in anaplastic glioma

Schliesser, Maximilian Georg ; Claus, Rainer ; Hielscher, Thomas ; Grimm, Christiane ; Weichenhan, Dieter ; Blaes, Jonas ; Wiestler, Benedikt ; Hau, Peter ; Schramm, Johannes ; Sahm, Felix ; Weiß, Elisa K. ; Weiler, Markus ; Baer, Constance ; Schmidt-Graf, Friederike ; Schackert, Gabriele ; Westphal, Manfred ; Hertenstein, Anne ; Roth, Patrick ; Galldiks, Norbert ; Hartmann, Christian ; Pietsch, Torsten ; Felsberg, Joerg ; Reifenberger, Guido ; Sabel, Michael Christoph ; Winkler, Frank ; von Deimling, Andreas ; Meisner, Christoph ; Vajkoczy, Peter ; Platten, Michael ; Weller, Michael ; Plass, Christoph ; Wick, Wolfgang



Abstract

The outcome of patients with anaplastic gliomas varies considerably depending on single molecular markers, such as mutations of the isocitrate dehydrogenase (IDH) genes, as well as molecular classifications based on epigenetic or genetic profiles. Remarkably, 98% of the RNA within a cell is not translated into proteins. Of those, especially microRNAs (miRNAs) have been shown not only to have a ...

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