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Targeted next-generation sequencing identifies molecular subgroups in squamous cell carcinoma of the head and neck with distinct outcome after concurrent chemoradiation

Tinhofer, I. ; Stenzinger, A. ; Eder, T. ; Konschak, R. ; Niehr, F. ; Endris, V. ; Distel, L. ; Hautmann, M.G. ; Mandic, R. ; Stromberger, C. ; Weichert, W. ; Budach, V.



Abstract

Background: Based on epidemiological (HPV status, smoking habits) and clinical risk factors (T/N stage), three subgroups of patients suffering from locally advanced oropharyngeal carcinoma with significantly different outcome after concurrent chemoradiation (cCRTX) can be distinguished. Mutational profiling by targeted next-generation sequencing (NGS) might further improve risk stratification. ...

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