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Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts

Busse, Hendrik ; Bitzinger, Diane ; Höcherl, Klaus ; Seyfried, Timo ; Gruber, Michael ; Graf, Bernhard M. ; Zausig, York A.



Abstract

Mechanical and morphological ischemia and reperfusion (I/R) injury is reduced in septic hearts. The mechanism behind this "cardioprotection" is less well understood. As adenosine receptors play a major role for cardioprotection in non-septic hearts, we investigated the influence of adenosine receptors in a model of I/R in septic hearts. SHAM operation or cecal ligation and puncture (CLP) was ...

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