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Epithelial–mesenchymal transition of the retinal pigment epithelium causes choriocapillaris atrophy

Ohlmann, Andreas ; Scholz, Michael ; Koch, Marcus ; Tamm, Ernst R.



Abstract

Epithelial-to-mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is commonly observed at sites of choroidal neovascularization in patients suffering from age-related macular degeneration. To learn in an experimental model how RPE EMT affects the biology of the choroidal vasculature, we studied transgenic mice (beta B1-TGF-beta 1) with ocular overexpression of transforming growth ...

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