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Repression of RNA polymerase by the archaeo-viral regulator ORF145/RIP

Sheppard, Carol ; Blombach, Fabian ; Belsom, Adam ; Schulz, Sarah ; Daviter, Tina ; Smollett, Katherine ; Mahieu, Emilie ; Erdmann, Susanne ; Tinnefeld, Philip ; Garrett, Roger ; Grohmann, Dina ; Rappsilber, Juri ; Werner, Finn


Little is known about how archaeal viruses perturb the transcription machinery of their hosts. Here we provide the first example of an archaeo-viral transcription factor that directly targets the host RNA polymerase (RNAP) and efficiently represses its activity. ORF145 from the temperate Acidianus two-tailed virus (ATV) forms a high-affinity complex with RNAP by binding inside the DNA-binding ...


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