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Myeloid Cell–Derived HIF-1α Promotes Control of Leishmania major

Schatz, Valentin ; Strüssmann, Yannic ; Mahnke, Alexander ; Schley, Gunnar ; Waldner, Maximilian ; Ritter, Uwe ; Wild, Jens ; Willam, Carsten ; Dehne, Nathalie ; Brüne, Bernhard ; McNiff, Jennifer M. ; Colegio, Oscar R. ; Bogdan, Christian ; Jantsch, Jonathan



Abstract

Hypoxia-inducible factor-1 alpha (HIF-1 alpha), which accumulates in mammalian host organisms during infection, supports the defense against microbial pathogens. However, whether and to what extent HIF-1 alpha expressed by myeloid cells contributes to the innate immune response against Leishmania major parasites is unknown. We observed that Leishmania-infected humans and L. majorinfected C57BL/6 ...

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