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Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors

Holtan, Shernan G. ; Khera, Nandita ; Levine, John E. ; Chai, Xiaoyu ; Storer, Barry ; Liu, Hien D. ; Inamoto, Yoshihiro ; Chen, George L. ; Mayer, Sebastian ; Arora, Mukta ; Palmer, Jeanne ; Flowers, Mary E. D. ; Cutler, Corey S. ; Lukez, Alexander ; Arai, Sally ; Lazaryan, Aleksandr ; Newell, Laura F. ; Krupski, Christa ; Jagasia, Madan H. ; Pusic, Iskra ; Wood, William ; Renteria, Anne S. ; Yanik, Gregory ; Hogan, William J. ; Hexner, Elizabeth ; Ayuk, Francis ; Holler, Ernst ; Watanaboonyongcharoen, Phandee ; Efebera, Yvonne A. ; Ferrara, James L. M. ; Panoskaltsis-Mortari, Angela ; Weisdorf, Daniel ; Lee, Stephanie J. ; Pidala, Joseph


Late acute (LA) graft-versus-host disease (GVHD) is persistent, recurrent, or new-onset acute GVHD symptoms occurring > 100 days after allogeneic hematopoietic cell transplantation (HCT). The aim of this analysis is to describe the onset, course, morbidity, and mortality of and examine angiogenic factors associated with LA GVHD. A prospective cohort of patients (n 5 909) was enrolled as part of ...


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