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Autotransplant with and without induction chemotherapy in older multiple myeloma patients: long-term outcome of a randomized trial

Straka, Christian ; Liebisch, Peter ; Salwender, Hans ; Hennemann, Burkhard ; Metzner, Bernd ; Knop, Stefan ; Adler-Reichel, Sigrid ; Gerecke, Christian ; Wandt, Hannes ; Bentz, Martin ; Bruemmendorf, Tim Hendrik ; Hentrich, Marcus ; Pfreundschuh, Michael ; Wolf, Hans-Heinrich ; Sezer, Orhan ; Bargou, Ralf ; Jung, Wolfram ; Trümper, Lorenz ; Hertenstein, Bernd ; Heidemann, Else ; Bernhard, Helga ; Lang, Nicola ; Frickhofen, Norbert ; Hebart, Holger ; Schmidmaier, Ralf ; Sandermann, Andreas ; Dechow, Tobias ; Reichle, Albrecht ; Schnabel, Brigitte ; Schäfer-Eckart, Kerstin ; Langer, Christian ; Gramatzki, Martin ; Hinke, Axel ; Emmerich, Bertold ; Einsele, Hermann


Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60-70 years were randomly assigned to 4 cycles of standard anthracycline-based induction chemotherapy or no induction. For all patients, double autologous transplantation ...


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