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Splenic pooling and loss of VCAM-1 causes an engraftment defect in patients with myelofibrosis after allogeneic hematopoietic stem cell transplantation

Hart, Christina ; Klatt, Sabine ; Barop, Johann ; Müller, Gunnar ; Schelker, Roland ; Holler, Ernst ; Huber, Elisabeth ; Herr, Wolfgang ; Grassinger, Jochen



Abstract

Myelofibrosis is a myeloproliferative neoplasm that results in cytopenia, bone marrow fibrosis and extramedullary hematopoiesis. Allogeneic hematopoietic stem cell transplantation is the only curative treatment but is associated with a risk of delayed engraftment and graft failure. In this study, patients with myelofibrosis (n= 31) and acute myeloid leukemia (n= 31) were analyzed for time to ...

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