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Health-related quality of life in patients with high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

Reijneveld, Jaap C. ; Taphoorn, Martin J. B. ; Coens, Corneel ; Bromberg, Jacoline E. C. ; Mason, Warren P. ; Hoang-Xuan, Khê ; Ryan, Gail ; Hassel, Mohamed Ben ; Enting, Roelien H. ; Brandes, Alba A. ; Wick, Antje ; Chinot, Olivier ; Reni, Michele ; Kantor, Guy ; Thiessen, Brian ; Klein, Martin ; Verger, Eugenie ; Borchers, Christian ; Hau, Peter ; Back, Michael ; Smits, Anja ; Golfinopoulos, Vassilis ; Gorlia, Thierry ; Bottomley, Andrew ; Stupp, Roger ; Baumert, Brigitta G.


Background Temozolomide chemotherapy versus radiotherapy in patients with a high-risk low-grade glioma has been shown to have no significant effect on progression-free survival. If these treatments have a different effect on health-related quality of life (HRQOL), it might affect the choice of therapy. We postulated that temozolomide compromises HRQOL and global cognitive functioning to a lesser ...


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