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TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice—Brief Report

Baig, Ayesha A. ; Haining, Elizabeth J. ; Geuss, Eva ; Beck, Sarah ; Swieringa, Frauke ; Wanitchakool, Podchanart ; Schuhmann, Michael K. ; Stegner, David ; Kunzelmann, Karl ; Kleinschnitz, Christoph ; Heemskerk, Johan W.M. ; Braun, Attila ; Nieswandt, Bernhard



Abstract

Objective-It is known that both platelets and coagulation strongly influence infarct progression after ischemic stroke, but the mechanisms and their interplay are unknown. Our aim was to assess the contribution of the procoagulant platelet surface, and thus platelet-driven thrombin generation, to the progression of thromboinflammation in the ischemic brain. Approach and Results-We present the ...

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