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Extracellular K+ rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl− -dependent and independent mechanisms

Penton, David ; Czogalla, Jan ; Wengi, Agnieszka ; Himmerkus, Nina ; Loffing-Cueni, Dominique ; Carrel, Monique ; Rajaram, Renuga Devi ; Staub, Olivier ; Bleich, Markus ; Schweda, Frank ; Loffing, Johannes


A high dietary potassium (K+) intake causes a rapid dephosphorylation, and hence inactivation, of the thiazide-sensitive NaCl cotransporter (NCC) in the renal distal convoluted tubule (DCT). Based on experiments in heterologous expression systems, it was proposed that changes in extracellular K+ concentration ([K+](ex)) modulate NCC phosphorylation via a Cl--dependent modulation of the with no ...


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