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Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide

Wick, Wolfgang ; Roth, Patrick ; Hartmann, Christian ; Hau, Peter ; Nakamura, Makoto ; Stockhammer, Florian ; Sabel, Michael C. ; Wick, Antje ; Koeppen, Susanne ; Ketter, Ralf ; Vajkoczy, Peter ; Eyupoglu, Ilker ; Kalff, Rolf ; Happold, Caroline ; Galldiks, Norbert ; Schmidt-Graf, Friederike ; Bamberg, Michael ; Reifenberger, Guido ; Platten, Michael ; von Deimling, Andreas ; Meisner, Christoph ; Wiestler, Benedikt ; Weller, Michael


Background. Optimal treatment and precise classification for anaplastic glioma are needed. Methods. The objective for long-term follow-up of NOA-04 is to optimize the treatment sequence for patients with anaplastic gliomas. Patients were randomized 2: 1: 1 to receive the standard radiotherapy (RT) (arm A), procarbazine, lomustine and vincristine (PCV) (arm B1), or temozolomide (TMZ) (arm B2). ...


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