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ESR1, ERBB2, and Ki67 mRNA expression predicts stage and grade of non-muscle-invasive bladder carcinoma (NMIBC)

Breyer, Johannes ; Wirtz, Ralph M. ; Laible, Mark ; Schlombs, Kornelia ; Erben, Philipp ; Kriegmair, Maximilian Christian ; Stoehr, Robert ; Eidt, Sebastian ; Denzinger, Stefan ; Burger, Maximilian ; Hartmann, Arndt ; Otto, Wolfgang



Abstract

Pathological staging and grading are crucial for risk assessment in non-muscle-invasive bladder cancer (NMIBC). Molecular grading might support pathological evaluation and minimize interobserver variability. In this study, the well-established breast cancer markers ESR1, PGR, ERBB2, and MKI67 were evaluated as potential molecular markers to support grading and staging in NMIBC. We retrospectively ...

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