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CD103+Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10–Producing Regulatory T Cells

Evers, Beatrix D.G. ; Engel, Daniel R. ; Böhner, Alexander M.C. ; Tittel, André P. ; Krause, Torsten A. ; Heuser, Christoph ; Garbi, Natalio ; Kastenmüller, Wolfgang ; Mack, Matthias ; Tiegs, Gisa ; Panzer, Ulf ; Boor, Peter ; Ludwig-Portugall, Isis ; Kurts, Christian


Kidney dendritic cells (DCs) regulate nephritogenic T cell responses. Most kidney DCs belong to the CD11b(+) subset and promote crescentic GN (cGN). The function of the CD103(+) subset, which represents <5% of kidney DCs, is poorly understood. We studied the role of CD103(+) DCs in cGN using several lines of genetically modified mice that allowed us to reduce the number of these cells. In all ...


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