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Salt-losing nephropathy in mice with a null mutation of the Clcnk2 gene

Grill, A. ; Schießl, I. M. ; Gess, B. ; Fremter, K. ; Hammer, A. ; Castrop, H.



Abstract

AimThe basolateral chloride channel ClC-Kb facilitates Cl reabsorption in the distal nephron of the human kidney. Functional mutations in CLCNKB are associated with Bartter's syndrome type 3, a hereditary salt-losing nephropathy. To address the function of ClC-K2 invivo, we generated ClC-K2-deficient mice. MethodsClC-K2-deficient mice were generated using TALEN technology. ResultsClC-K2-deficient ...

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