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Ceramide and polyunsaturated phospholipids are strongly reduced in human hepatocellular carcinoma

Krautbauer, Sabrina ; Meier, Elisabeth M. ; Rein-Fischboeck, Lisa ; Pohl, Rebekka ; Weiss, Thomas S. ; Sigruener, Alexander ; Aslanidis, Charalampos ; Liebisch, Gerhard ; Buechler, Christa



Abstract

Lipid composition affects membrane function, cell proliferation and cell death and is changed in cancer tissues. Hepatocellular carcinoma (HCC) is an aggressive cancer and this study aimed at a comprehensive characterization of hepatic and serum lipids in human HCC. Cholesteryl ester were higher in tumorous tissues (TT) compared to adjacent non-tumorous tissues (NT). Free cholesterol exerting ...

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