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Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

Jungk, Christine ; Mock, Andreas ; Exner, Janina ; Geisenberger, Christoph ; Warta, Rolf ; Capper, David ; Abdollahi, Amir ; Friauf, Sara ; Lahrmann, Bernd ; Grabe, Niels ; Beckhove, Philipp ; von Deimling, Andreas ; Unterberg, Andreas ; Herold-Mende, Christel


Background: The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers. Methods: mRNA microarray data of a discovery set (n = 36 GBMs) were analyzed for SVZ-dependent ...


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