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Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion

Koehler, Sybille ; Brähler, Sebastian ; Kuczkowski, Alexander ; Binz, Julia ; Hackl, Matthias J. ; Hagmann, Henning ; Höhne, Martin ; Vogt, Merly C. ; Wunderlich, Claudia M. ; Wunderlich, F. Thomas ; Schweda, Frank ; Schermer, Bernhard ; Benzing, Thomas ; Brinkkoetter, Paul T.


Chronic alterations in calcium (Ca2+) signalling in podocytes have been shown to cause proteinuria and progressive glomerular diseases. However, it is unclear whether short Ca2+ peaks influence glomerular biology and cause podocyte injury. Here we generated a DREADD (Designer Receptor Exclusively Activated by a Designer Drug) knock-in mouse line to manipulate intracellular Ca2+ levels. By mating ...


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