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Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene

Pink, Matthias ; Ratsch, Boris A. ; Mardahl, Maibritt ; Durek, Pawel ; Polansky, Julia K. ; Karl, Martin ; Baumgrass, Ria ; Wallner, Stefan ; Cadenas, Cristina ; Gianmoena, Kathrin ; Floess, Stefan ; Chen, Wei ; Nordstroem, Karl ; Tierling, Sascha ; Olek, Sven ; Walter, Jörn ; Hamann, Alf ; Syrbe, Uta



Abstract

E- and P-selectin ligands (E- and P-ligs) guide effector memory T cells into skin and inflamed regions, mediate the inflammatory recruitment of leukocytes, and contribute to the localization of hematopoietic precursor cells. A better understanding of their molecular regulation is therefore of significant interest with regard to therapeutic approaches targeting these pathways. In this study, we ...

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