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P144, a Transforming Growth Factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines

Gallo-Oller, Gabriel ; Vollmann-Zwerenz, Arabel ; Meléndez, Bárbara ; Rey, Juan A. ; Hau, Peter ; Dotor, Javier ; Castresana, Javier S.



Abstract

Glioblastoma (GBM) is the most prevalent malignant primary brain tumor, accounting for 60-70% of all gliomas. Current median patient survival time is 14-16 months after diagnosis. Numerous efforts in therapy have not significantly altered the nearly uniform lethality of this malignancy. The Transforming Growth Factor beta (TGF-beta) signaling pathway plays a key role in GBM and is implicated in ...

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