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Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis

Willeit, Peter ; Kaptoge, Stephen ; Welsh, Paul ; Butterworth, Adam S ; Chowdhury, Rajiv ; Spackman, Sarah A ; Pennells, Lisa ; Gao, Pei ; Burgess, Stephen ; Freitag, Daniel F ; Sweeting, Michael ; Wood, Angela M ; Cook, Nancy R ; Judd, Suzanne ; Trompet, Stella ; Nambi, Vijay ; Olsen, Michael Hecht ; Everett, Brendan M ; Kee, Frank ; Ärnlöv, Johan ; Salomaa, Veikko ; Levy, Daniel ; Kauhanen, Jussi ; Laukkanen, Jari A ; Kavousi, Maryam ; Ninomiya, Toshiharu ; Casas, Juan-Pablo ; Daniels, Lori B ; Lind, Lars ; Kistorp, Caroline N ; Rosenberg, Jens ; Mueller, Thomas ; Rubattu, Speranza ; Panagiotakos, Demosthenes B ; Franco, Oscar H ; de Lemos, James A ; Luchner, Andreas ; Kizer, Jorge R ; Kiechl, Stefan ; Salonen, Jukka T ; Wannamethee, S Goya ; de Boer, Rudolf A ; Nordestgaard, Børge G ; Andersson, Jonas ; Jørgensen, Torben ; Melander, Olle ; Ballantyne, Christie M ; DeFilippi, Christopher ; Ridker, Paul M ; Cushman, Mary ; Rosamond, Wayne D ; Thompson, Simon G ; Gudnason, Vilmundur ; Sattar, Naveed ; Danesh, John ; Di Angelantonio, Emanuele



Abstract

Background Guidelines for primary prevention of cardiovascular diseases focus on prediction of coronary heart disease and stroke. We assessed whether or not measurement of N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration could enable a more integrated approach than at present by predicting heart failure and enhancing coronary heart disease and stroke risk assessment. Methods In ...

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