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Diagnosis of invasive fungal infections in haematological patients by combined use of galactomannan, 1,3-β-D-glucan, Aspergillus PCR, multifungal DNA-microarray, and Aspergillus azole resistance PCRs in blood and bronchoalveolar lavage samples: results of a prospective multicentre study

Boch, T. ; Spiess, B. ; Cornely, O.A. ; Vehreschild, J.J. ; Rath, P.M. ; Steinmann, J. ; Heinz, W.J. ; Hahn, J. ; Krause, S.W. ; Kiehl, M.G. ; Egerer, G. ; Liebregts, T. ; Koldehoff, M. ; Klein, M. ; Nolte, F. ; Mueller, M.C. ; Merker, N. ; Will, S. ; Mossner, M. ; Popp, H. ; Hofmann, W.-K. ; Reinwald, M. ; Buchheidt, D.



Abstract

High mortality rates of invasive fungal disease (IFD), especially invasive aspergillosis (IA), in immuno-compromised haematological patients and current diagnostic limitations require improvement of detection of fungal pathogens by defining the optimal use of biomarkers and clinical samples. Concurrent bronchoalveolar lavage (BAL) and peripheral blood samples of 99 haematological patients with ...

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