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Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration

Ramesh, Vidya ; Bayam, Efil ; Cernilogar, Filippo M. ; Bonapace, Ian M. ; Schulze, Markus ; Riemenschneider, Markus J. ; Schotta, Gunnar ; Götz, Magdalena


In order to understand whether early epigenetic mechanisms instruct the long-term behavior of neural stem cells (NSCs) and their progeny, we examined Uhrf1 (ubiquitin-like PHD ring finger-1; also known as Np95), as it is highly expressed in NSCs of the developing brain and rapidly down-regulated upon differentiation. Conditional deletion of Uhrfl in the developing cerebral cortex resulted in ...


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