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Quantitative detection of TUSC3 promoter methylation -a potential biomarker for prognosis in lung cancer

Duppel, Uta ; Woenckhaus, Matthias ; Schulz, Christian ; Merk, Johannes ; Dietmaier, Wolfgang



Abstract

Aberrant promoter methylation of tumor relevant genes frequently occurs in early steps of carcinogenesis and during tumor progression. Epigenetic alterations could be used as potential biomarkers for early detection and for prediction of prognosis and therapy response in lung cancer. The present study quantitatively analyzed the methylation status of known and potential gatekeeper and tumor ...

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