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Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease: Final Results From the International Compassionate-Use Program

Corbacioglu, Selim ; Carreras, Enric ; Mohty, Mohamad ; Pagliuca, Antonio ; Boelens, Jaap Jan ; Damaj, Gandhi ; Iacobelli, Massimo ; Niederwieser, Dietger ; Olavarría, Eduardo ; Suarez, Felipe ; Ruutu, Tapani ; Verdonck, Leo ; Hume, Robin ; Nejadnik, Bijan ; Lai, Chinglin ; Finetto, Giorgia ; Richardson, Paul



Abstract

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable and potentially fatal complication of hematopoietic cell transplantation (HCT) or nontransplantation-associated chemotherapy/radiotherapy. In cases of severe hepatic VOD/SOS, typically defined by associated multiorgan failure (MOF, also known as multiorgan dysfunction), mortality exceeds ...

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