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Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist

Riedl, Moritz ; Witzmann, Christina ; Koch, Matthias ; Lang, Siegmund ; Kerschbaum, Maximilian ; Baumann, Florian ; Krutsch, Werner ; Docheva, Denitsa ; Alt, Volker ; Pfeifer, Christian
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Date of publication of this fulltext: 26 Mar 2020 15:18


Abstract

In vitro chondrogenically differentiated mesenchymal stem cells (MSCs) have a tendency to undergo hypertrophy, mirroring the fate of transient “chondrocytes” in the growth plate. As hypertrophy would result in ossification, this fact limits their use in cartilage tissue engineering applications. During limb development, retinoic acid receptor (RAR) signaling exerts an important influence on cell ...

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