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Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study

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Simon, Philipp ; Busse, David ; Petroff, David ; Dorn, Christoph ; Ehmann, Lisa ; Hochstädt, Sophie ; Girrbach, Felix ; Dietrich, Arne ; Zeitlinger, Markus ; Kees, Frieder ; Kloft, Charlotte ; Wrigge, Hermann
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Date of publication of this fulltext: 15 Apr 2020 08:54


Background: Linezolid is used for the treatment of soft tissue infections in critically ill patients. However, data for characterizing the pharmacokinetics (PK) and assessing whether effective concentrations are reached at the target site are lacking. We hypothesized that current dosing regimens do not lead to effective concentrations in the plasma and interstitial fluid (ISF) of subcutaneous ...


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