What is the Role of Acid-Acid Interactions in Asymmetric Phosphoric Acid Organocatalysis? A Detailed Mechanistic Study using Interlocked and Non-Interlocked Catalysts

URN to cite this document:: urn:nbn:de:bvb:355-epub-430659
DOI to cite this document:: 10.5283/epub.43065

Jansen, D. ; Gramüller, J. ; Niemeyer, F. ; Schaller, T. ; Letzel, M. C. ; Grimme, S. ; Zhu, H. ; Gschwind, Ruth M.

; Niemeyer, J.

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Date of publication of this fulltext: 20 Apr 2020 10:42

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Abstract

Organocatalysis has revolutionized asymmetric synthesis. However, the supramolecular interactions of organocatalysts in solution are often neglected, although the formation of catalyst aggregates can have a strong impact on the catalytic reaction. For phosphoric acid based organocatalysts, we have now established that catalyst-catalyst interactions can be suppressed by using macrocyclic ...