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Risk of target non-attainment In obese compared to non-obese patients In Calculated linezolid therapy

Ehmann, L. ; Simon, P. ; Busse, D. ; Petroff, D. ; Dorn, Christoph ; Huisinga, W. ; Dietrich, A. ; Zeitlinger, M. ; Wrigge, H. ; Kloft, C.



Abstract

OBJECTIVES: To characterise linezolid population pharmacokinetics in plasma and interstitial space fluid of subcutaneous adipose tissue (target-site) of obese compared to non-obese patients and to determine dosing regimens enabling adequate therapy using Monte Carlo simulations. METHODS: In this prospective, parallel group, open-label, controlled single-centre trial 30 surgery patients (15 ...

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