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Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

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Lin, Dasheng ; Alberton, Paolo ; Delgado Caceres, Manuel ; Prein, Carina ; Clausen‐Schaumann, Hauke ; Dong, Jian ; Aszodi, Attila ; Shukunami, Chisa ; Iatridis, James C. ; Docheva, Denitsa
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 06 May 2020 15:07


The intervertebral disc (IVD) degeneration is thought to be closely related to ingrowth of new blood vessels. However, the impact of anti-angiogenic factors in the maintenance of IVD avascularity remains unknown. Tenomodulin (Tnmd) is a tendon/ligament-specific marker and anti-angiogenic factor with abundant expression in the IVD. It is still unclear whether Tnmd contributes to the maintenance of ...


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