Loss of tenomodulin expression is a risk factor for age‐related intervertebral disc degeneration

URN to cite this document:: urn:nbn:de:bvb:355-epub-431247
DOI to cite this document:: 10.5283/epub.43124

Lin, Dasheng ; Alberton, Paolo ; Delgado Caceres, Manuel ; Prein, Carina ; Clausen‐Schaumann, Hauke

; Dong, Jian ; Aszodi, Attila ; Shukunami, Chisa ; Iatridis, James C. ; Docheva, Denitsa

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Date of publication of this fulltext: 06 May 2020 15:07

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Abstract

The intervertebral disc (IVD) degeneration is thought to be closely related to ingrowth of new blood vessels. However, the impact of anti-angiogenic factors in the maintenance of IVD avascularity remains unknown. Tenomodulin (Tnmd) is a tendon/ligament-specific marker and anti-angiogenic factor with abundant expression in the IVD. It is still unclear whether Tnmd contributes to the maintenance of ...