Age-dependent effects of the onset of a conductive hearing loss on the volume of the cochlear nucleus subdivisions and the expression of c-fos in the mongolian gerbil (Meriones unguiculatus)

DOI to cite this document:

10.5283/epub.4315 Copy

Gleich, Otto ; Strutz, Jürgen

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Date of publication of this fulltext: 05 Aug 2009 13:46

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Details

Item type:	Article
Journal or Publication Title:	Audiology and Neurotology
Publisher:	Karger
Volume:	2
Number of Issue or Book Chapter:	3
Page Range:	pp. 113-127
Date:	1997
Institutions:	Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde
Keywords:	Development; Maturation; Deprivation; Deafness; Cochlear nucleus morphology
Dewey Decimal Classification:	500 Science > 590 Zoological sciences 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	4315

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Abstract

A monaural conductive hearing loss was induced by interrupting the chain of the middle ear ossicles on the right side in gerbils of four different age groups (P12-14, P20-21, P42 and P84). The volumes of the cochlear nucleus subdivisions and the number of cells that expressed immunoreactivity for c-fos after noise stimulation were determined on the left and right side in the deprived animals, and ...

Abstract

A monaural conductive hearing loss was induced by interrupting the chain of the middle ear ossicles on the right side in gerbils of four different age groups (P12-14, P20-21, P42 and P84). The volumes of the cochlear nucleus subdivisions and the number of cells that expressed immunoreactivity for c-fos after noise stimulation were determined on the left and right side in the deprived animals, and in undeprived control animals when they reached the age of 6 months. The anteroventral cochlear nucleus on the deprived side was reduced in volume when the deprivation started before the age of 3 months. The other cochlear nucleus subdivisions showed no systematic age-dependent reductions. The expression of c-fos in the dorsal cochlear nucleus appeared more resistant to a hearing loss, with deprivation being more effective in younger animals. c-fos expression was also dramatically reduced in the ventral cochlear nucleus, regardless of age at the onset of hearing loss.

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