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Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A

Centeio, Raquel ; Cabrita, Inês ; Benedetto, Roberta ; Talbi, Khaoula ; Ousingsawat, Jiraporn ; Schreiber, Rainer ; Sullivan, John K. ; Kunzelmann, Karl
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Date of publication of this fulltext: 12 May 2020 12:33


Abstract

TMEM16A is a Ca2+ activated Cl− channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl− secretion and to enhance airway surface liquid (ASL). This CFTR-agnostic approach is thought to improve mucociliary clearance and lung function in CF. This could indeed improve ASL, ...

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