| Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (7MB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-431800
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.43180
Zusammenfassung
TMEM16A is a Ca2+ activated Cl- channel with important functions in airways, intestine, and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic fibrosis (CF) to reinstall airway Cl- secretion and to enhance airway surface liquid (ASL). This CFTR-agnostic approach is thought to improve mucociliary clearance and lung function in CF. This could indeed improve ASL, ...
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