Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

URN to cite this document:: urn:nbn:de:bvb:355-epub-431846
DOI to cite this document:: 10.5283/epub.43184

Reinders, Jörg ; Altenbuchinger, Michael ; Limm, Katharina

; Schwarzfischer, Philipp ; Scheidt, Tamara ; Strasser, Lisa ; Richter, Julia ; Szczepanowski, Monika ; Huber, Christian G.

; Klapper, Wolfram ; Spang, Rainer

; Oefner, Peter J.

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Date of publication of this fulltext: 13 May 2020 08:22

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Abstract

Diffuse large B-cell lymphoma (DLBCL) is commonly classified by gene expression profiling according to its cell of origin (COO) into activated B-cell (ABC)-like and germinal center B-cell (GCB)-like subgroups. Here we report the application of label-free nano-liquid chromatography - Sequential Window Acquisition of all THeoretical fragment-ion spectra - mass spectrometry (nanoLC-SWATH-MS) to the ...