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Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

Reinders, Jörg ; Altenbuchinger, Michael ; Limm, Katharina ; Schwarzfischer, Philipp ; Scheidt, Tamara ; Strasser, Lisa ; Richter, Julia ; Szczepanowski, Monika ; Huber, Christian G. ; Klapper, Wolfram ; Spang, Rainer ; Oefner, Peter J.
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Date of publication of this fulltext: 13 May 2020 08:22


Abstract

Diffuse large B-cell lymphoma (DLBCL) is commonly classified by gene expression profiling according to its cell of origin (COO) into activated B-cell (ABC)-like and germinal center B-cell (GCB)-like subgroups. Here we report the application of label-free nano-liquid chromatography - Sequential Window Acquisition of all THeoretical fragment-ion spectra – mass spectrometry (nanoLC-SWATH-MS) to the ...

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