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Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1

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Minderjahn, Julia ; Schmidt, Andreas ; Fuchs, Andreas ; Schill, Rudolf ; Raithel, Johanna ; Babina, Magda ; Schmidl, C. ; Gebhard, Claudia ; Schmidhofer, Sandra ; Mendes, Karina ; Ratermann, Anna ; Glatz, Dagmar ; Nützel, Margit ; Edinger, Matthias ; Hoffmann, Petra ; Spang, Rainer ; Längst, Gernot ; Imhof, A. ; Rehli, Michael
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Date of publication of this fulltext: 18 May 2020 14:31


Establishing gene regulatory networks during differentiation or reprogramming requires master or pioneer transcription factors (TFs) such as PU.1, a prototype master TF of hematopoietic lineage differentiation. To systematically determine molecular features that control its activity, here we analyze DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic ...


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