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Dendritic integration in olfactory bulb granule cells:
Thresholds for lateral inhibition and role of active conductances upon 3D multi-site photostimulation of spines using a holographic projector module

URN to cite this document:
urn:nbn:de:bvb:355-epub-432458
Müller, Max
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Dissertation
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Date of publication of this fulltext: 27 May 2020 09:07


Abstract (English)

The inhibitory axonless olfactory bulb granule cells (OB GCs) form reciprocal dendrodendritic synapses with mitral and tufted cells (MCs and TCs) via large spines, mediating recurrent and lateral inhibition. Rat GC dendrites are excitable by local Na⁺ spine spikes and global Ca²⁺- and Na⁺-spikes. Since reaching global threshold potentials also represents the onset of lateral inhibition, the goal ...

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Translation of the abstract (German)

Die GABAergen inhibitorischen axonlosen Körnerzellen (GCs) bilden über lange Dornfortsätze (Spines) reziproke dendrodendritische Synapsen mit Mitral- und Büschelzellen (MC/TCs), den wichtigsten Projektionsneuronen des Riechkolbens von Säugern (Bulbus Olfactorius, OB), aus. Diese Synapsen vermitteln die Selbstinhibition von und laterale Inhibition zwischen MC/TCs. Diese dient der ...

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