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Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation

Pinto, Madalena C. ; Schreiber, Rainer ; Lerias, Joana ; Ousingsawat, Jiraporn ; Duarte, Aires ; Amaral, Margarida ; Kunzelmann, Karl
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Date of publication of this fulltext: 16 Jun 2020 15:27


Abstract

Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels in cancer cells, where it inhibits apoptosis, and supports cell migration and proliferation. The Ca2+-activated chloride channel TMEM16A shows ...

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