Photocatalytic Reductive Radical‑Polar Crossover for a Base‑Free Corey‑Seebach Reaction

URN to cite this document:: urn:nbn:de:bvb:355-epub-435545
DOI to cite this document:: 10.5283/epub.43554

Donabauer, Karsten ; Murugesan, Kathiravan ; Rozman, Urša ; Crespi, Stefano

; König, Burkhard

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Date of publication of this fulltext: 06 Aug 2020 07:54

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Abstract

A metal-free generation of carbanion nucleophiles is of prime importance in organic synthesis. Herein we report a photocatalytic approach to the Corey-Seebach reaction. The presented method operates under mild redox-neutral and base-free conditions giving the desired product with high functional group tolerance. The reaction is enabled by the combination of photo- and hydrogen atom transfer (HAT) ...