Copper(II)-Photocatalyzed N−H Alkylation with Alkanes

URN to cite this document:: urn:nbn:de:bvb:355-epub-436145
DOI to cite this document:: 10.5283/epub.43614

Zheng, Yi-Wen ; Narobe, Rok ; Donabauer, Karsten ; Yakubov, Shaboz ; König, Burkhard

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Date of publication of this fulltext: 20 Aug 2020 04:56

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Abstract

We report a practical method for the alkylation of N-H bonds with alkanes using a photoinduced copper(II) peroxide catalytic system. Upon light irradiation, the peroxide serves as a hydrogen atom transfer reagent to activate stable C(sp(3))-H bonds for the reaction with a broad range of nitrogen nucleophiles. The method enables the chemoselective alkylation of amides and is utilized for the ...