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Identification of metastasis founder cells in breast cancer by cell lineage tracing

URN to cite this document:
urn:nbn:de:bvb:355-epub-439555
DOI to cite this document:
10.5283/epub.43955
Ghosh, Manjusha S.
Date of publication of this fulltext: 29 Sep 2021 05:57


Abstract (English)

Background: Metastatic dissemination often occurs at early stages of breast cancer progression implying that disseminated cancer cells (DCCs) evolve outside the primary tumor in a process of selection and adaptation. To identify metastasis founder cells in humans we strived to construct cell lineage trees by longitudinally tracking genetic changes in cancer cells isolated from patients at various ...

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Translation of the abstract (German)

Hintergrund: Die Metastasierung tritt häufig in frühen Stadien der Brustkrebsprogression auf, was bedeutet, dass sich die disseminierten Krebszellen (DCCs) in einem Selektions- und Anpassungsprozess außerhalb des Primärtumors entwickeln. Um Metastasen-Gründerzellen beim Menschen zu identifizieren, haben wir versucht, Zellstammbäume zu konstruieren, indem wir genetische Veränderungen in ...

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