Effects of Alemtuzumab on (Auto) antigen-Specific Immune Responses

URN to cite this document:: urn:nbn:de:bvb:355-epub-439784
DOI to cite this document:: 10.5283/epub.43978

Weissert, Robert

; Hilger, Clara ; Riedhammer, Christine ; Orsó, Evelyn

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Date of publication of this fulltext: 02 Nov 2020 12:00

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Abstract

Alemtuzumab (anti-CD52 mAb) leads to a long-lasting disease activity suppression in patients with relapsing forms of multiple sclerosis (MS). In this study, we examined the change of the immune cell repertoire and the cellular reactivity after treatment with alemtuzumab. We analyzed the number of IFN-gamma-secreting cells in presence of several peptides which had been eluted from the central ...