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Insights into the mechanisms of the antimicrobial photodynamic action toward biofilms using phenalen-1-one derivatives as photosensitizers

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Muehler, Denise ; Rupp, Christina ; Keceli, Sercan ; Brochhausen, Christoph ; Siegmund, Heiko ; Maisch, Tim ; Hiller, Karl-Anton ; Buchalla, Wolfgang ; Cieplik, Fabian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Nov 2020 11:55


Introduction: In view of increasing resistance against antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a promising approach for use in dentistry. The aim of this study was to investigate the mechanism of action of aPDT with the phenalene-1-one derivatives SAPYR and SA-PN-05 as photosensitizers by evaluating bacterial ability to replicate, membrane integrity, ...


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