Chemerin-156 is the Active Isoform in Human Hepatic Stellate Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-439989
DOI to cite this document:: 10.5283/epub.43998

Spirk, Marlen ; Zimny, Sebastian ; Neumann, Maximilian ; McMullen, Nichole ; Sinal, Christopher J. ; Buechler, Christa

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Date of publication of this fulltext: 02 Nov 2020 13:16

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Abstract

The chemokine chemerin exists as C-terminally processed isoforms whose biological functions are mostly unknown. A highly active human chemerin variant (huChem-157) was protective in experimental hepatocellular carcinoma (HCC) models. Hepatic stellate cells (HSCs) are central mediators of hepatic fibrogenesis and carcinogenesis and express the chemerin receptors chemokine-like receptor 1 (CMKLR1) ...