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Chemerin-156 is the Active Isoform in Human Hepatic Stellate Cells

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Spirk, Marlen ; Zimny, Sebastian ; Neumann, Maximilian ; McMullen, Nichole ; Sinal, Christopher J. ; Buechler, Christa
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Nov 2020 13:16


The chemokine chemerin exists as C-terminally processed isoforms whose biological functions are mostly unknown. A highly active human chemerin variant (huChem-157) was protective in experimental hepatocellular carcinoma (HCC) models. Hepatic stellate cells (HSCs) are central mediators of hepatic fibrogenesis and carcinogenesis and express the chemerin receptors chemokine-like receptor 1 (CMKLR1) ...


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