Retinoschisin and Cardiac Glycoside Crosstalk at the Retinal Na/K-ATPase

URN to cite this document:: urn:nbn:de:bvb:355-epub-440254
DOI to cite this document:: 10.5283/epub.44025

Schmid, Verena ; Plössl, Karolina ; Schmid, Carina ; Bernklau, Sarah ; Weber, Bernhard H. F.

; Friedrich, Ulrike

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Date of publication of this fulltext: 02 Nov 2020 13:18

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Abstract

PURPOSE. Mutations in the RS1 gene, which encodes retinoschisin, cause X-linked juvenile retinoschisis, a retinal dystrophy in males. Retinoschisin specifically interacts with the retinal sodium-potassium adenosine triphosphatase (Na/K-ATPase), a transmembrane ion pump. Na/K-ATPases also bind cardiac glycosides, which control the activity of the pump and have been linked to disturbances in ...