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Early OA Stage Like Response Occurs after Dynamic Stretching of Human Synovial Fibroblasts

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Nazet, Ute ; Grässel, Susanne ; Jantsch, Jonathan ; Proff, Peter ; Schröder, Agnes ; Kirschneck, Christian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Nov 2020 11:34


As events triggering early osteoarthritis onset can be related to mechanical stress and proinflammatory signaling, we investigated the effect of different mechanical strain protocols on the expression of proinflammatory genes, as well as extracellular matrix remodelling in human synovial fibroblasts. Three distinct models of tensile stretching were applied: static isotropic tensile strain at 0 ...


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