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Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling

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Schreiber, Rainer ; Ousingsawat, Jiraporn ; Kunzelmann, Karl
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Nov 2020 11:32


Anoctamins such as TMEM16A and TMEM16B are Ca2+-dependent Cl- channels activated through purinergic receptor signaling. TMEM16A (ANO1), TMEM16B (ANO2) and TMEM16F (ANO6) are predominantly expressed at the plasma membrane and are therefore well accessible for functional studies. While TMEM16A and TMEM16B form halide-selective ion channels, TMEM16F and probably TMEM16E operate as phospholipid ...


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