Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model

URN to cite this document:: urn:nbn:de:bvb:355-epub-440384
DOI to cite this document:: 10.5283/epub.44038

Pattappa, Girish

; Krueckel, Jonas ; Schewior, Ruth ; Franke, Dustin ; Mench, Alexander ; Koch, Matthias ; Weber, Johannes ; Lang, Siegmund

; Pfeifer, Christian G.

; Johnstone, Brian

; Docheva, Denitsa

; Alt, Volker ; Angele, Peter ; Zellner, Johannes

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Date of publication of this fulltext: 02 Nov 2020 11:25

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Abstract

Focal early osteoarthritis (OA) or degenerative lesions account for 60% of treated cartilage defects each year. The current cell-based regenerative treatments have an increased failure rate for treating degenerative lesions compared to traumatic defects. Mesenchymal stem cells (MSCs) are an alternative cell source for treating early OA defects, due to their greater chondrogenic potential, ...