A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors

URN to cite this document:: urn:nbn:de:bvb:355-epub-440746
DOI to cite this document:: 10.5283/epub.44074

Forster, Lisa

; Grätz, Lukas ; Mönnich, Denise ; Bernhardt, Günther ; Pockes, Steffen

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(4MB)

Date of publication of this fulltext: 12 Jan 2021 15:09

Alternative links to fulltext:DOI Publisher Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Investigations on functional selectivity of GPCR ligands have become increasingly important to identify compounds with a potentially more beneficial side effect profile. In order to discriminate between individual signaling pathways, the determination of beta-arrestin2 recruitment, in addition to G-protein activation, is of great value. In this study, we established a sensitive split ...