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A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors

URN to cite this document:
urn:nbn:de:bvb:355-epub-440746
DOI to cite this document:
10.5283/epub.44074
Forster, Lisa ; Grätz, Lukas ; Mönnich, Denise ; Bernhardt, Günther ; Pockes, Steffen
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 12 Jan 2021 15:09


Abstract

Investigations on functional selectivity of GPCR ligands have become increasingly important to identify compounds with a potentially more beneficial side effect profile. In order to discriminate between individual signaling pathways, the determination of beta-arrestin2 recruitment, in addition to G-protein activation, is of great value. In this study, we established a sensitive split ...

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